Observatory: Viagra as Diet Pill?

New evidence suggests that the erectile-dysfunction drug Viagra might have another use: helping burn away excess fat.

The drug, generically known as sildenafil, helped convert undesirable white fat cells to energy-burning beige fat cells in laboratory mice, researchers at the University of Bonn in Germany report in The Journal of the Federation of American Societies for Experimental Biology.

It was already known that mice fed Viagra became less prone to obesity when fed a high-fat diet. What was not clear was why.

Dr. Alexander Pfeifer, director of the university’s Institute for Pharmacology and Toxicology, said he already had some clues: Viagra works by preventing the degradation of the intercellular messenger cGMP. Dr. Pfeifer has long been testing the effects of cGMP on fat cells.

So he fed the drug to mice for seven days and monitored their fat cells. As it turned out, the troublesome white fat cells, which are associated with human problems like the dreaded spare tire, were being converted to the beneficial type of fat cells at a higher rate than usual. Dr. Pfeifer called the results “very promising.”

Still, he cautions against taking the drug purely for dieting purposes. “The idea to have one pill and then obesity goes away, that is a dream, but not easy to come by,” he said. “What we are up to is basic research in mice. This pill is approved by the F.D.A. for a particular purpose for a reason.” 

Read More..

A Conversation With Nick Goldman: Using DNA to Store Digital Information

European Molecular Biology Laboratory

Nick Goldman, a molecular biologist at the European Bioinformatics Institute in Hinxton, England, used a technique with error-correction software to store and retrieve data in synthetic DNA molecules.

Last Wednesday, a group of researchers at the European Bioinformatics Institute reported in the journal Nature that they had managed to store digital information in synthetic DNA molecules, then recreated the original digital files without error.

The amount of data, 739 kilobytes all told, is hardly prodigious by today’s microelectronic storage standards: all 154 of Shakespeare’s sonnets, a scientific paper, a color digital photo of the researchers’ laboratory, a 26-second excerpt from the Rev. Dr. Martin Luther King Jr.’s “I have a dream” speech and a software algorithm. Nor is this the first time digital information has been stored in DNA.

But the researchers said their new technique, which includes error-correction software, was a step toward a digital archival storage medium of immense scale. Their goal is a system that will safely store the equivalent of one million CDs in a gram of DNA for 10,000 years.

If the new technology proves workable, it will have arrived just in time. The lead author, the British molecular biologist Nick Goldman, said he had conceived the idea with a colleague, Ewan Birney, while the two sat in a pub pondering the digital fire hose of genetic information their institute is now receiving — and the likelihood that it would soon outpace even today’s chips and disk drives, whose capacity continues to double roughly every two years, as predicted by Moore’s law.

The telephone interview with Dr. Goldman, from his laboratory in Hinxton, near Cambridge, has been edited and condensed.

Does your experiment suggest that DNA is a reasonable alternative for archiving digital information?

It’s too far beyond us at the moment because of the price. I don’t know if there are enough machines to write DNA in big quantities. I suspect not. The experiment we did converted about three-quarters of a megabyte of information off a hard disk drive into DNA. We showed it worked on a large scale, and part of what we published is an analysis of how that might scale up, at least theoretically. But we couldn’t do the scale-up experiments.

You’ve proved something. What’s next?

We’ve got a couple of ideas to pursue to make this a bit more likely to be something to turn up in the real world. One is to improve the coding and the decoding to see if we can get more information into the same amount of DNA. Hopefully if we can store twice as much information, that will halve our costs.

We were quite conservative in the approach we took. We really wanted to make sure that it worked, and so we used quite a lot of error-correction code. We could maybe sacrifice less to the error-correction part and use more actual information.

The other thing to make it work on a scale that the world would really be interested in is to automate and miniaturize. All the technologies exist — they’re all commercially available. But they’re not all in one place, and they’re not designed to work with each other as such.

If you wanted to do it properly you’d invest in the site, you’d have DNA synthesis at the site, you’d have the storage there, you’d have the reading back in one place, and you’d miniaturize it all. You’d have micro-fluidics to do what is currently lab science — even to the level of having robots to do the filing of the test tubes onto shelves. Robots are used in magnetic tape archive centers now, and you’d just want a smaller version of the same.

How similar is what you’ve done to what is involved in today’s gene-sequencing systems, which read and store the proteins in a DNA molecule?

The sequencing, or reading it back, that we did is exactly the same. We designed it that way. We designed it so that it would work in the standard protocols that we and our laboratory collaborators are familiar with, day in day out. It is really exactly the same process. We use an Illumina sequencing machine.

The writing of the information is a technology I’m a little bit less familiar with. But Agilent Technologies, whom we worked with, is one of the world leaders in developing this, and it is, I believe, very much like an inkjet printing system. But you’re not using colored dyes on paper — you’re using chemical solutions that include in them the nucleotides, the basis of DNA, fired very accurately onto a glass slide so that each little spot on the slide you build up is a separate sequence.

Is there a category of information you were most interested in archiving?

Read More..

Egypt’s Morsi Declares State of Emergency

CAIRO (AP) — Egypt's president declared a state of emergency and curfew in three Suez Canal provinces hit hardest by a weekend wave of unrest that left more than 50 dead, using tactics of the ousted regime to get a grip on discontent over his Islamist policies and the slow pace of change.

Angry and almost screaming, Mohammed Morsi vowed in a televised address on Sunday night that he would not hesitate to take even more action to stem the latest eruption of violence across much of the country. But at the same time, he sought to reassure Egyptians that his latest moves would not plunge the country back into authoritarianism.

"There is no going back on freedom, democracy and the supremacy of the law," he said.

The worst violence this weekend was in the Mediterranean coastal city of Port Said, where seven people were killed on Sunday, pushing the toll for two days of clashes to at least 44. The unrest was sparked on Saturday by a court conviction and death sentence for 21 defendants involved in a mass soccer riot in the city's main stadium on Feb. 1, 2012 that left 74 dead.

Most of those sentenced to death were local soccer fans from Port Said, deepening a sense of persecution that Port Said's residents have felt since the stadium disaster, the worst soccer violence ever in Egypt.

At least another 11 died on Friday elsewhere in the country during rallies marking the second anniversary of the anti-Mubarak uprising. Protesters used the occasion to renounce Morsi and his Islamic fundamentalist group, the Muslim Brotherhood, which emerged as the country's most dominant political force after Mubarak's ouster.

The curfew and state of emergency, both in force for 30 days, affect the provinces of Port Said, Ismailiya and Suez. The curfew takes effect Monday from 9 p.m. to 6 a.m. every day.

Morsi, in office since June, also invited the nation's political forces to a dialogue starting Monday to resolve the country's latest crisis. A statement issued later by his office said that among those invited were the country's top reform leader, Nobel peace Laureate Mohammed ElBaradei, former Arab League chief Amr Moussa and Hamdeen Sabahi, a leftist politician who finished third in last year's presidential race.

The three are leaders of the National Salvation Front, an umbrella for the main opposition parties.

Khaled Dawoud, the Front's spokesman, said Morsi's invitation was meaningless unless he clearly states what is on the agenda. That, he added, must include amending a disputed constitution hurriedly drafted by the president's Islamist allies and rejected by the opposition.

He also faulted the president for not acknowledging his political responsibility for the latest bout of political violence.

"It is all too little too late," he told The Associated Press.

In many ways, Morsi's decree and his call for a dialogue betrayed his despair in the face of wave after wave of political unrest, violence and man-made disasters that, at times, made the country look like it was about to come unglued.

A relative unknown until his Muslim Brotherhood nominated him to run for president last year, Morsi is widely criticized for having offered no vision for the country's future after nearly 30 years of dictatorship under Mubarak and no coherent policy to tackle seemingly endless problems, from a free falling economy and deeply entrenched social injustices to surging crime and chaos on the streets.

Reform of the judiciary and the police, hated under the old regime for brutality, are also key demands of Morsi's critics.

Morsi did not say what he plans to do to stem the violence in other parts of the country outside those three provinces, but he did say he had instructed the police to deal "firmly and forcefully" with individuals attacking state institutions, using firearms to "terrorize" citizens or blocking roads and railway lines.

There were also clashes Sunday in Cairo and several cities in the Nile Delta region, including the industrial city of Mahallah.

Read More..

Djokovic completes Australian Open hat trick

MELBOURNE, Australia (AP) — No shirt ripping or bare-chested flexing this time.

Novak Djokovic completed his work before midnight, defeating Andy Murray in four sets for his third consecutive Australian Open title and fourth overall.

It was also the second time in three years Djokovic had beaten his longtime friend in this final. So the celebration was muted: a small victory shuffle, raised arms, a kiss for the trophy. No grand histrionics, although that's not to say the moment was lost on him.

"Winning it three in a row, it's incredible," Djokovic said after his 6-7 (2), 7-6 (3), 6-3, 6-2 victory Sunday night. "It's very thrilling. I'm full of joy right now. It's going to give me a lot of confidence for the rest of the season, that's for sure."

Nine other men had won consecutive Australian titles in the Open era, but none three straight years. One of them was Andre Agassi, who presented Djokovic with the trophy.

A year ago, Djokovic began his season with an epic 5-hour, 53-minute five-set win over Rafael Nadal at the Australian Open, the longest Grand Slam final. He tore off his shirt to celebrate, the TV replays repeated constantly at this tournament.

He mimicked that celebration after coming back to beat Stanislas Wawrinka in five hours in a surprisingly tough fourth-round victory this time.

Since then, he's looked every bit the No. 1 player. He said he played "perfectly" in his 89-minute win over fourth-seeded David Ferrer in the semifinals Thursday night. Murray struggled to beat 17-time major winner Roger Federer in five sets in the semifinals Friday night, and still had the bad blisters on his feet to show for it in the final.

In a final that had the makings of a classic when two of the best returners in tennis were unable to get a break of serve in the first two sets that lasted 2:13, the difference may have hinged on something as light as a feather.

Preparing for a second serve at 2-2 in the second set tiebreaker, Murray was rocking back about to toss the ball when he stopped, paused and then walked onto the court and tried to grab a small white feather that was floating in his view. He went back to the baseline, bounced the ball another eight times and served too long.

After being called for a double-fault, Murray knocked the ball away in anger and flung his arm down. He didn't get close for the rest of the tiebreaker and was the first to drop serve in the match — in the eighth game of the third set. Djokovic broke him twice in the fourth set, which by then had turned into an easy march to victory.

"It was strange," said Djokovic, adding that it swung the momentum his way. "It obviously did. ... He made a crucial double-fault."

Murray didn't blame his loss on the one distraction.

"I mean, I could have served. It just caught my eye before I served. I thought it was a good idea to move it," he said. "Maybe it wasn't because I obviously double-faulted.

"You know, at this level it can come down to just a few points here or there. My biggest chance was at the beginning of the second set — didn't quite get it. When Novak had his chance at the end of the third, he got his."

Djokovic had five break-point chances in the opening set, including four after having Murray at 0-40 in the seventh game, but wasn't able to convert any of them.

Then he surrendered the tiebreaker with six unforced errors. Murray appeared to be the stronger of the two at the time. He'd beaten Djokovic in their last Grand Slam encounter, the U.S. Open final, and had the Serb so off balance at times in the first set that he slipped to the court and took skin off his knee.

Murray held serve to open the second set and had three break points at 0-40 in the second game, but Djokovic dug himself out of trouble and held.

"After that I felt just mentally a little bit lighter and more confident on the court than I've done in the first hour or so," Djokovic said. "I was serving better against him today in the first two sets than I've done in any of the match in the last two years."

Djokovic said he loves playing at Rod Laver Arena, where he won his first major title in 2008. He now has six Grand Slam titles altogether. Federer has won four of his 17 majors at Melbourne Park, and Agassi is the only other player to have won that many in Australia since 1968.

Djokovic was just finding his way at the top level when Agassi retired in 2006, but he had watched enough of the eight-time major winner to appreciate his impact.

"He's I think one of the players that changed the game — not just the game itself, but also the way the people see it," Djokovic said. "So it was obviously a big pleasure and honor for me to receive the trophy from him."

Agassi was among the VIPs in the crowd, along with actor Kevin Spacey and Victoria Azarenka, who won the women's final in three sets against Li Na the previous night.

Murray broke the 76-year drought for British men at the majors when he won the U.S. Open last year and said he'll leave Melbourne slightly more upbeat than he has after defeats here in previous years.

"The last few months have been the best tennis of my life. I mean, I made Wimbledon final, won the Olympics, won the U.S. Open. You know, I was close here as well," he said. "No one's ever won a slam (immediately) after winning their first one. It's not the easiest thing to do. And I got extremely close.

"So, you know, I have to try and look at the positives of the last few months, and I think I'm going the right direction."

Read More..

Brain Aging Linked to Sleep-Related Memory Decline

Scientists have known for decades that the ability to remember newly learned information declines with age, but it was not clear why. A new study may provide part of the answer.

The report, posted online on Sunday by the journal Nature Neuroscience, suggests that structural brain changes occurring naturally over time interfere with sleep quality, which in turn blunts the ability to store memories for the long term.

Previous research had found that the prefrontal cortex, the brain region behind the forehead, tends to lose volume with age, and that part of this region helps sustain quality sleep, which is critical to consolidating new memories. But the new experiment, led by researchers at the University of California, Berkeley, is the first to directly link structural changes with sleep-related memory problems.

The findings suggest that one way to slow memory decline in aging adults is to improve sleep, specifically the so-called slow-wave phase, which constitutes about a quarter of a normal night’s slumber.

Doctors cannot reverse structural changes that occur with age any more than they can turn back time. But at least two groups are experimenting with electrical stimulation as a way to improve deep sleep in older people. By placing electrodes on the scalp, scientists can run a low current across the prefrontal area, essentially mimicking the shape of clean, high-quality slow waves.

The result: improved memory, at least in some studies. “There are also a number of other ways you can improve sleep, including exercise,” said Ken Paller, a professor of psychology and the director of the cognitive neuroscience program at Northwestern University, who was not involved in the research.

Dr. Paller said that a whole array of changes occurred across the brain during aging and that sleep was only one factor affecting memory function.

But Dr. Paller said the study told “a convincing story, I think: that atrophy is related to slow-wave sleep, which we know is related to memory performance. So it’s a contributing factor.”

In the study, the research team took brain images from 19 people of retirement age and from 18 people in their early 20s. It found that a brain area called the medial prefrontal cortex, roughly behind the middle of the forehead, was about one-third smaller on average in the older group than in the younger one — a difference due to natural atrophy over time, previous research suggests.

Before bedtime, the team had the two groups study a long list of words paired with nonsense syllables, like “action-siblis” and “arm-reconver.” The team used the nonwords because one type of memory that declines with age is for new, previously unseen information.

After training on the pairs for half an hour or so, the participants took a test on some of them. The young group outscored the older group by about 25 percent.

Then everyone went to bed — and bigger differences emerged. For one, the older group got only about a quarter of the amount of high-quality slow-wave sleep that the younger group did, as measured by the shape and consistency of electrical waves on an electroencephalogram machine, or EEG. It is thought that the brain moves memories from temporary to longer-term storage during this deep sleep.

On a second test, given in the morning, the younger group outscored the older group by about 55 percent. The estimated amount of atrophy in each person roughly predicted the difference between his or her evening and morning scores, the study found. Even seniors who were very sharp at night showed declines after sleeping.

“The analysis showed that the differences were due not to changes in capacity for memories, but to differences in sleep quality,” said Bryce A. Mander, a postdoctoral fellow at Berkeley and the lead author of the study. His co-authors included researchers from the California Pacific Medical Center in San Francisco; the University of California, San Diego; and the Lawrence Berkeley National Laboratory.

The findings do not imply that medial prefrontal atrophy is the only age-related change causing memory problems, said Matthew P. Walker, a professor of psychology and neuroscience at Berkeley and a co-author of the study.

“Essentially, with age, you lose tissue in this prefrontal area,” Dr. Walker said. “You get less quality deep sleep, and have less opportunity to consolidate new memories.”

Read More..

Exam Finds Nothing Unusual About a Second Boeing 787 Battery

WASHINGTON — Although a fire destroyed one of two big batteries on a Boeing 787 parked at Logan Airport in Boston three weeks ago, a quick examination of the second battery found “no obvious anomalies,” the National Transportation Safety Board said on Sunday.

The second battery was of identical design but used for a different purpose than the first, the agency said. Its report added scattered details to what is known about the incident, one of two battery problems that led to the grounding of all 50 of the 787s in airline service.

The board said that its laboratory was continuing to study the destroyed battery, whose function was to start the auxiliary power unit, a small jet engine used mostly on the ground. The battery, which was not being charged or discharged, caught fire on Jan. 7 while the plane was empty.

The undamaged battery on which the board reported Sunday was a backup for cockpit instruments, located near the nose. The board has released photos of the damaged and undamaged batteries.

On Jan. 16, on a different 787 on a domestic flight in Japan, the main battery began belching smoke a few minutes after takeoff, forcing an emergency landing. Investigators have not said whether it was being charged at the time. The planes were grounded shortly afterward.

The batteries use a lithium-ion chemistry, which has been in use for many years in many applications but is new in airplanes. Investigators say the problem could be the batteries or with the associated electronics used to manage them.

The board said Sunday that at the time of the fire at Logan, the plane, which belonged to Japan Airlines, had completed 22 flights and 169 flight hours.

The board’s update also said that investigators had completed a review of two systems associated with the auxiliary power unit, at two locations in Arizona, and found no problems.

The board said it had sent two additional investigators to Seattle, where the board was working with the Federal Aviation Administration to review work at Boeing. One investigator will work with a group reviewing Boeing’s corrective actions, and the other will work on how the lithium-ion batteries were approved by the F.A.A.

The safety board is an advisory body with no regulatory authority — that belongs to the F.A.A. — but it is in charge of safety investigations.

A team led by the safety board also examined circuit boards used to monitor the battery in the in-flight incident in Japan, the board said. The circuit boards were damaged in the incident, “which limited the information that could be obtained from tests,” the board said. It added that the team “found no significant discoveries.”

Read More..

The Saturday Profile: Leading the Tunisian Agency That Once Jailed Him

TUNIS — It was the first time Ali Laarayedh had inspected a prison cell, but even then, as the interior minister, his old instincts kicked in.

“I turned around to see who would shut the cell door on me,” he said in his quiet manner.

But no one bolted the door. For Mr. Laarayedh had experienced a profound reversal of fortune, mirroring that of the Islamist political party that he helped found. Jailed numerous times in the Interior Ministry as a political prisoner, he now runs the very security agency that once sent him to death row.

His memory of the cells remains vivid. “Even though they are on the ground floor,” he said, “once you are inside them you have the impression that you have entered a cave.”

Mr. Laarayedh, 57, speaking in his office at a considerable distance above the cells, argued that his grueling prison experiences make him a better minister, sensitive to the abuse of power and the need for not just Tunisia, but all Arab states, to bend their omnipotent secret police to the rule of law.

Others are not convinced of his commitment to the law, at least not in the Western style. Mr. Laarayedh was imprisoned repeatedly, including all the years from 1990 to 2004, for being a founding member of the Renaissance Party, or Ennahda in Arabic, the Islamist political party that dominates Tunisia’s first elected post-revolutionary government.

Many in the opposition suspect that when men like Mr. Laarayedh talk about the rule of law, they mean Shariah, or Islamic law, a Koran-based code that is often at odds with Western standards of justice. The minister has also been widely criticized for the level of violence the police still unleash to squelch protests.

The interior minister is one of at least eight cabinet ministers, about one-third of the total, who spent significant chunks of their adult lives behind bars, often in solitary confinement. Some Tunisians believe that a country struggling with unemployment and political upheaval would be better off run by technocrats rather than veteran prisoners lacking real-world experience.

After one notorious episode on Sept. 14, when the American Embassy was sacked, critics mocked Mr. Laarayedh mercilessly for saying essentially that security forces had protected the embassy’s front door, but unfortunately the marauders entered through the back. Since that melee, which left four people dead, the police have been unable to apprehend Seifallah Ben Hassine, the leader of the puritanical Salafi movement, who is wanted for helping to inspire it.

In the interview, the minister said his forces were overwhelmed that day by a lack of equipment, including armored vehicles needed to protect the police. On the larger issue of governance, he argued that Tunisia was better off in the hands of those who sacrificed for change.

“We have to choose people who can break with the past and put the country on the path to democracy and a state of law,” said Mr. Laarayedh. “If we go back to the old, to the people with experience, nothing will change.”

He prefers not to detail his own imprisonment, saying that political detainees of all stripes had to endure the same terrible physical and mental torture. Many died or lost their minds, he said; as for himself, his physical scars are not visible, so it is better to focus on the revolution. When pressed, however, he revealed some contained anger.

“One of the worst forms of torture is when they leave you all alone,” he said. “When you pound on the iron door, if you are sick or you need something, and you can pound all night and they do not respond. Believe me, that is the worst contempt and the worst violence that I experienced. They take you for a mouse or a fly, or for nothing at all. You do not exist. You are not even worth being beaten. Do you understand? You are not even worth being beaten.”

He can put that behind him, he said, mostly because the revolution succeeded. “I realized all my objectives — a dictator fell, a democracy for which I gave my life was born and Tunisians are masters of their own destiny,” he said.

Mr. Laarayedh said he worried more about the effect his long absences had on his wife, a medical technician, and his three children, as he dedicated his life to political activism.

After obtaining a degree in maritime engineering in 1980, he worked for the government for only a year before going underground. He had odd jobs like teaching math in private schools, and he even got married in 1983 while on the run. His long years in and out of prison began around 1987.

Those years instilled in him the need for Tunisia to reach an equilibrium, he said, for a government able to curb the excesses of both the religious zealots and the liberals. Each camp accuses him of coddling the other.

“I don’t want the state to be hostage to either of these extremist tendencies,” he said.

He denied that the Renaissance Party worked in collusion with the more puritanical Salafis, who have staged a series of violent protests against art galleries and other liberal institutions. “We try to compromise between modernity, with all its values, and our own authenticity, our Arab Muslim identity,” he said, whereas the Salafis create “an antagonism between the present and the past.”

Some activists, particularly women, remain skeptical. Tunisia had perhaps the most progressive Arab gender laws for decades, and they believe that the Renaissance Party is shrinking the public space for women. They had hoped for something different given that while underground, the Islamists had emphasized the universal rights of man.

Olfa el-Alem, a political organizer, noted that despite repeated promises to investigate police violence against demonstrators, no results had been publicized.

“I thought the day they gained their liberty they would let others have their freedom as well,” said Ms. Alem, referring to the Renaissance leaders.

Mr. Laarayedh and other Renaissance leaders suggested that they lack full control over the levers of state. Mr. Laarayedh said Tunisians cannot yet take their nascent democracy for granted.

“This used to be Ben Ali’s desk!” he said, beaming, as he showed a visitor his office. Zine el-Abidine Ben Ali, the leader deposed by the January 2011 revolution, was prime minister when he seized the presidency in a bloodless 1987 coup.

Perhaps the best testament to the fact that democracy will emerge from Tunisia’s ferment, Mr. Laarayedh said, is that he now sits at that desk.

“It is a miracle,” he said. “If you want to look for irrefutable evidence that there was a revolution here, it is that someone condemned to death by this very ministry has become the minister.”

This article has been revised to reflect the following correction:

Correction: January 26, 2013

An earlier version of this article misidentified the title held by Zine el-Abidine Ben Ali when he seized the presidency in 1987. He was prime minister, not interior minister.

Read More..

Smartphone 4Q sales rise 36 pct led by Samsung

SAN FRANCISCO (AP) — Smartphone shipments rose 36 percent worldwide in the fourth quarter as the sleek devices supplanted personal computers and other gadgets on holiday shopping lists, according to a report released Friday.

The findings from the research firm International Data Corp. are the latest sign of the technology upheaval being wrought by the growing popularity of smartphones that can perform a wide variety of tasks, including surfing the Web and taking high-quality photos.

Companies whose fortunes are tied to the PC industry have been particularly hard hit by the shift to smartphones and tablet computers.

While some smartphone models were in short supply during the holiday season, fourth-quarter PC shipments fell by 6 percent from the previous year, according to another IDC report released earlier this month.

IDC estimates 219 million smartphones were shipped during the final three months of last year. That compares with nearly 161 million in the same 2011 period. Smartphones accounted for about 45 percent of all mobile phone shipments in the fourth quarter, the highest percentage recorded by IDC.

Samsung Electronics Co. retained its bragging rights as the smartphone leader, shipping nearly 64 million devices for a 29 percent share of the global market.

Apple Inc. ranked second with nearly 48 million iPhones shipped during the fourth quarter, translating into a market share of 22 percent.

For all of 2012, IDC estimated nearly 713 million smartphones were shipped worldwide, a 44 percent increase from the previous year. Meanwhile, annual PC shipments fell 3 percent from 2011, IDC said. It was the first annual decline since 2001.

Entering 2012, Apple held a slight edge over Samsung in the smartphone market. But Samsung sprinted past Apple during the year as it introduced an array of models, most of which run on Google Inc.‘s free Android software. Samsung’s top-selling line, the Galaxy, boasts larger display screens than the iPhone and other features.

Apple alleges Samsung’s devices illegally ripped off the iPhone’s innovations. After a high-profile trial in federal court, a jury in San Jose, Calif. sided with some of the patent infringement claims last August and decided Samsung should pay more than $ 1 billion in damages. Samsung has been trying to overturn the verdict.

Lower-priced smartphones from Samsung and other device makers also have hurt Apple, whose slowing iPhone growth has contributed to a $ 250 billion decline in its market value since its stock price peaked in late September.

IDC says Huawei Technologies Ltd.‘s emphasis on less expensive handsets helped it become the third largest smartphone maker with a market share of 5 percent at the end of the fourth quarter.

Gadgets News Headlines – Yahoo! News

Title Post: Smartphone 4Q sales rise 36 pct led by Samsung
Url Post: http://www.news.fluser.com/smartphone-4q-sales-rise-36-pct-led-by-samsung/
Link To Post : Smartphone 4Q sales rise 36 pct led by Samsung
Rating:
100%

based on 99998 ratings.
5 user reviews.
Author: Fluser SeoLink
Thanks for visiting the blog, If any criticism and suggestions please leave a comment

Read More..

Stan Musial remembered during funeral Mass

ST. LOUIS (AP) — Stan Musial was remembered during a funeral and memorial outside Busch Stadium on Saturday as a Hall of Famer and a St. Louis icon embraced by generations of fans who never had the privilege of watching him play.

Broadcaster Bob Costas, his voice cracking with emotion at times, pointed out during a two-hour Mass that in 92 years of life, Stan the Man never let anyone down.

Costas noted that even though Musial, who died Jan. 19, was a three-time NL MVP and seven-time batting champion, the pride of Donora, Pa., lacked a singular achievement. Joe DiMaggio had a 56-game hitting streak, Ted Williams was the last major leaguer to hit .400, and Willie Mays and Mickey Mantle soared to stardom in the New York spotlight. Musial didn't quite reach the 500-homer club — he finished with 475 — and played in his final World Series in 1946, "wouldn't you know it, the year before they started televising the Fall Classic!"

"What was the hook with Stan Musial other than the distinctive stance and the role of one of baseball's best hitters?" Costas said. "It seems that all Stan had going for him was more than two decades of sustained excellence as a ballplayer and more than nine decades as a thoroughly decent human being.

"Where is the single person to truthfully say a bad word about him?"

There was enough room in the large Roman Catholic church for a handful of fans. One of them wore a vintage, No. 6 Musial jersey. Another clapped softly as pallbearers carried the casket from the church to the hearse to the tune of bagpipes.

Among those in attendance were baseball Commissioner Bud Selig, former St. Louis standout Albert Pujols and Hall of Famers Bob Gibson, Lou Brock, Ozzie Smith, Bruce Sutter, Whitey Herzog and 90-year-old Red Schoendienst, who once roomed with Musial. Joe Torre, a former MVP and manager in St. Louis, and Tony La Russa, who became close with Musial during his 16 seasons managing the Cardinals, sat near the front along with current manager Mike Matheny.

Pujols, who had been on track to challenge many of Musial's franchise records before signing with the Angels 13 months ago, exchanged hugs with Fred Hanser, a member of the Cardinals ownership team, before taking his seat.

Jim Edmonds, a star center fielder for two World Series teams in the 2000s, has the same last name as one of Musial's sons-in-law. He said Musial informed him that they were distant relatives, and greeted him as "Hey, Cuz!"

"I thought he was kidding at first," Edmonds said. "That's pretty cool."

Jack Clark, a slugging first baseman for the Cardinals during the 1980s, said he perhaps respected Musial most for his decency during baseball's sometimes difficult period of integration in the 1940s and 1950s.

"Stan kind of crossed that color barrier. When people were getting on the African-American players, he stuck up for them. It was a time when you could kind of get your finger pointed at you for that stuff," Clark said. "People loved him, and he loved them right back."

Bishop Richard Stika, pastor at Musial's' church in suburban St. Louis for several years, speculated during the homily about why Musial was never ejected from a game during his career: "I think deep down, that was because he didn't want to go home and face Lil."

Musial's wife of nearly 72 years, Lillian, died last year.

Grandson Andrew Edmonds said the public Musial was no different from the private Musial, the grandpa who bought McDonalds for the family every Sunday. He recalled a fan telling him, "Your grandpa's best attribute is he made nobodies feel like somebodies."

Pallbearers included Cardinals President Bill DeWitt III, Musial grandsons Andrew Edmonds and Brian Schwarze, and the retired star's longtime business partner in Stan the Man Inc., Dick Zitzmann.

After the service, the hearse and vans filled with the Cardinals' delegation drove to Busch Stadium, where Musial's family laid flowers at the base of one of his statues — the one that made the move across the street from the old Busch — while being serenaded by "Take Me Out to the Ball Game." Color guards from the city's fire and police departments flanked the statue, along with more than a dozen ballpark ushers. A single Clydesdale walked slowly down the street.

Cardinals closer Jason Motte shook his head.

"This is nothing like I've ever seen," he said.

During a funeral that was almost entirely upbeat, son-in-law Martin Schwarze got the biggest laugh when he recounted a 1995 radio interview with Jack Buck during which Musial was asked how good of a hitter he'd have been had he played in the modern era. Musial, who finished with a .331 career batting average, replied he probably would have batted about .275, and Buck said "Whoa, whoa, whoa," that's way too low.

Then Musial added with a chuckle, "Hey, Jack, I'm 75!"

Thousands filed through the Cathedral Basilica at Musial's six-hour public visitation on Thursday, and hundreds more attended the service.

Hundreds more were waiting at the more prominent of the two Musial statues outside Busch Stadium, where fans have gathered since Musial died after several years of declining health. Next to the statues were flowers, balloons, teddy bears, helmets, autographed items and a homemade sign that read "Thanks for the memories. You live in our hearts, No. 6."

"He's been a hero to us for four generations," Kathy Noorman of Wentzville, Mo., said, speaking near the statue. "He was such a good man, somebody you can hold up to grandkids and your own kids as an example of who they should be."

Mark Springman, 57, of Alton, Ill., brought a bottle of champagne to the statue shrine. He saw Musial play in 1963, Stan the Man's final season, and has been a season-ticket holder for about 15 years.

"He was more than a ballplayer," Springman said. "He was the man."

Read More..

Religious Groups and Employers Battle Contraception Mandate

Shawn Thew/European Pressphoto Agency

President Obama, with his health secretary, Kathleen Sebelius, offering a compromise on the contraception mandate last year.

In a flood of lawsuits, Roman Catholics, evangelicals and Mennonites are challenging a provision in the new health care law that requires employers to cover birth control in employee health plans — a high-stakes clash between religious freedom and health care access that appears headed to the Supreme Court.

In recent months, federal courts have seen dozens of lawsuits brought not only by religious institutions like Catholic dioceses but also by private employers ranging from a pizza mogul to produce transporters who say the government is forcing them to violate core tenets of their faith. Some have been turned away by judges convinced that access to contraception is a vital health need and a compelling state interest. Others have been told that their beliefs appear to outweigh any state interest and that they may hold off complying with the law until their cases have been judged. New suits are filed nearly weekly.

“This is highly likely to end up at the Supreme Court,” said Douglas Laycock, a law professor at the University of Virginia and one of the country’s top scholars on church-state conflicts. “There are so many cases, and we are already getting strong disagreements among the circuit courts.”

President Obama’s health care law, known as the Affordable Care Act, was the most fought-over piece of legislation in his first term and was the focus of a highly contentious Supreme Court decision last year that found it to be constitutional.

But a provision requiring the full coverage of contraception remains a matter of fierce controversy. The law says that companies must fully cover all “contraceptive methods and sterilization procedures” approved by the Food and Drug Administration, including “morning-after pills” and intrauterine devices whose effects some contend are akin to abortion.

As applied by the Health and Human Services Department, the law offers an exemption for “religious employers,” meaning those who meet a four-part test: that their purpose is to inculcate religious values, that they primarily employ and serve people who share their religious tenets, and that they are nonprofit groups under federal tax law.

But many institutions, including religious schools and colleges, do not meet those criteria because they employ and teach members of other religions and have a broader purpose than inculcating religious values.

“We represent a Catholic college founded by Benedictine monks,” said Kyle Duncan, general counsel of the Becket Fund for Religious Liberty, which has brought a number of the cases to court. “They don’t qualify as a house of worship and don’t turn away people in hiring or as students because they are not Catholic.”

In that case, involving Belmont Abbey College in North Carolina, a federal appeals court panel in Washington told the college last month that it could hold off on complying with the law while the federal government works on a promised exemption for religiously-affiliated institutions. The court told the government that it wanted an update by mid-February.

Defenders of the provision say employers may not be permitted to impose their views on employees, especially when something so central as health care is concerned.

“Ninety-nine percent of women use contraceptives at some time in their lives,” said Judy Waxman, a vice president of the National Women’s Law Center, which filed a brief supporting the government in one of the cases. “There is a strong and legitimate government interest because it affects the health of women and babies.”

She added, referring to the Centers for Disease Control and Prevention, “Contraception was declared by the C.D.C. to be one of the 10 greatest public health achievements of the 20th century.”

Officials at the Justice Department and the Health and Human Services Department declined to comment, saying the cases were pending.

A compromise for religious institutions may be worked out. The government hopes that by placing the burden on insurance companies rather than on the organizations, the objections will be overcome. Even more challenging cases involve private companies run by people who reject all or many forms of contraception.

The Alliance Defending Freedom — like Becket, a conservative group — has brought a case on behalf of Hercules Industries, a company in Denver that makes sheet metal products. It was granted an injunction by a judge in Colorado who said the religious values of the family owners were infringed by the law.

“Two-thirds of the cases have had injunctions against Obamacare, and most are headed to courts of appeals,” said Matt Bowman, senior legal counsel for the alliance. “It is clear that a substantial number of these cases will vindicate religious freedom over Obamacare. But it seems likely that the Supreme Court will ultimately resolve the dispute.”

The timing of these cases remains in flux. Half a dozen will probably be argued by this summer, perhaps in time for inclusion on the Supreme Court’s docket next term. So far, two- and three-judge panels on four federal appeals courts have weighed in, granting some injunctions while denying others.

One of the biggest cases involves Hobby Lobby, which started as a picture framing shop in an Oklahoma City garage with $600 and is now one of the country’s largest arts and crafts retailers, with more than 500 stores in 41 states.

David Green, the company’s founder, is an evangelical Christian who says he runs his company on biblical principles, including closing on Sunday so employees can be with their families, paying nearly double the minimum wage and providing employees with comprehensive health insurance.

Mr. Green does not object to covering contraception but considers morning-after pills to be abortion-inducing and therefore wrong.

“Our family is now being forced to choose between following the laws of the land that we love or maintaining the religious beliefs that have made our business successful and have supported our family and thousands of our employees and their families,” Mr. Green said in a statement. “We simply cannot abandon our religious beliefs to comply with this mandate.”

The United States Court of Appeals for the 10th Circuit last month turned down his family’s request for a preliminary injunction, but the company has found a legal way to delay compliance for some months.

Read More..